Trial intelligence / Profile preview

Telmisartan in Preventing Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients

NCT07370506Phase 2

Key facts

Status
Not yet recruiting
Start
Feb 2026
Primary completion
Jan 2027
Countries
1
Sponsor
Tanta University
Modality
Small Molecules
Conditions
doxorubicin-induced cardiomyopathy
01

Overview

Phase 2 trial of telmisartan in doxorubicin-induced cardiomyopathy (2 arms), sponsored by Tanta University. Primary endpoint: Change in Left Ventricular Ejection Fraction. Planned start Feb 2026; status: not yet recruiting.

02

Design

2 arms
  • Telmisartan Group

    Participants receiving telmisartan in addition to standard doxorubicin-based chemotherapy.

  • Control Group

    Participants receiving standard doxorubicin-based chemotherapy without telmisartan.

03

Who it enrols

Female breast cancer patients aged 18-65, newly diagnosed and chemotherapy-naïve, with baseline LVEF >= 55%, excluding those with cardiovascular, liver, or renal disease, high blood pressure, or prior ARB/ACE inhibitor use.

04

Endpoints

Primary

  • Change in Left Ventricular Ejection Fraction

Secondary

  • Change in High-Sensitivity Cardiac Troponin T Levels

  • Change in N-terminal pro-B-type Natriuretic Peptide Levels

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