FREEDOM Trial: MRgFUS in Advanced Parkinson's Disease

Randomised, single-blind trial in Parkinson's disease (PD) (5 arms), sponsored by Insightec. Primary endpoints: Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale Part III Upper/Lower Extremity score in the OFF-medication state (unilateral treatment) at 3 months and Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale Part III Upper/Lower Extremity score in the OFF-medication state (bilateral treatment) at 3 months. Planned start Sep 2026; status: not yet recruiting.