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Methotrexate effects on male fertility parameters in immune-mediated disease
NL-OMON20969Recruiting
- Sponsor
- Erasmus MC
- Start
- Feb 2019
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Countries
- 1
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Overview
Open-label trial of methotrexate in rheumatoid arthritis (RA), spondyloarthritis (SpA), juvenile idiopathic arthritis (JIA) and 4 more (2 arms), sponsored by Erasmus MC. Primary endpoint: Methotrexate quantification in seminal fluid and spermatozoa. Started Feb 2019; status: recruiting.
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Drugs
methotrexate
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Conditions
rheumatoid arthritis (RA)spondyloarthritis (SpA)juvenile idiopathic arthritis (JIA)undifferentiated arthritis (UA)psoriasis
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