Trial intelligence / Profile preview

Phase Ib pediatric study of crizotinib-based therapy in ALK/MET/ROS1-positive malignancies

NL-OMON24969Phase 1Recruiting

Sponsor
Erasmus MC
Start
Jun 2016
Modality
Small Molecules
Countries
1
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Overview

Phase 1, open-label trial of crizotinib, vinblastine and temsirolimus in anaplastic large cell lymphoma (ALCL), neuroblastoma, rhabdomyosarcoma (RMS) and 3 more, sponsored by Erasmus MC. Primary endpoints: Dose-limiting toxicities and Overall response rate. Started Jun 2016; status: recruiting.

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Drugs

crizotinibvinblastinetemsirolimus
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Conditions

anaplastic large cell lymphoma (ALCL)neuroblastomarhabdomyosarcoma (RMS)solid tumorNonhematologic neoplasms

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