Norepinephrine pharmacokinetics and pharmacodynamics before and during general anesthesia in healthy volunteers

Open-label, single-arm trial of norepinephrine, sponsored by University Medical Center Groningen. Primary endpoints: Association between arterial blood pressure and plasma norepinephrine concentration in the awake state and Association between arterial blood pressure and plasma norepinephrine concentration during steady-state general anesthesia. Planned start Apr 2021; status: not yet recruiting.