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Bortezomib + dexamethasone induction followed by high-dose melphalan and autologous stem cell transplantation in newly diagnosed AL amyloidosis
NL-OMON39975Phase 2Active, not recruiting
- Sponsor
- HOVON
- Start
- Mar 2012
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Reversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Small Molecules
- Countries
- 1
01
Overview
Phase 2, open-label, single-arm trial of bortezomib, dexamethasone and melphalan in light-chain amyloidosis, sponsored by HOVON. Primary endpoint: Hematologic complete response rate at 6 months after autologous stem cell transplantation. Started Mar 2012; status: active, not recruiting.
02
Drugs
bortezomibdexamethasonemelphalan
03
Conditions
light-chain amyloidosis
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