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Pilot study of intracellular methotrexate measurements to predict toxicity during high-dose methotrexate therapy
NL-OMON47317Not yet recruiting
- Sponsor
- Erasmus MC
- Start
- Nov 2015
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Countries
- 1
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Overview
Open-label, single-arm trial of methotrexate in central nervous system lymphoma and acute lymphoblastic leukemia (ALL), sponsored by Erasmus MC. Primary endpoint: Intracellular methotrexate levels (polyglutamates). Planned start Nov 2015; status: not yet recruiting.
02
Drugs
methotrexate
03
Conditions
central nervous system lymphomaacute lymphoblastic leukemia (ALL)
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