Trial intelligence / Profile preview

Randomized trial of matched unrelated versus haploidentical donor allogeneic stem cell transplantation with identical GVHD prophylaxis in acute leukemia and high-risk MDS

NL-OMON52639Active, not recruiting

Sponsor
University Medical Center Hamburg-Eppendorf
Start
Dec 2023
Modality
RNA-Targeting Small Molecules → Nucleic Acid-Directed Small Molecules → Small Molecules, Small Molecules, Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Randomised, open-label trial of cyclophosphamide, tacrolimus, mycophenolate mofetil, fludarabine and busulfan in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and myelodysplastic syndrome (MDS) (2 arms), sponsored by University Medical Center Hamburg-Eppendorf. Primary endpoint: Relapse incidence at 2 years. Started Dec 2023; status: active, not recruiting.

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Drugs

cyclophosphamidetacrolimusmycophenolate mofetilfludarabinebusulfan
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Conditions

acute myeloid leukemia (AML)acute lymphoblastic leukemia (ALL)myelodysplastic syndrome (MDS)

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