Trial intelligence / Profile preview

MC2 TCR-engineered T-cell therapy with epigenetic pretreatment for MAGE-C2-positive melanoma or head and neck cancer

NL-OMON52657Phase 1Recruiting

Sponsor
Erasmus MC
Start
Oct 2020
Modality
TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Countries
1
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Overview

Phase 1, open-label, single-arm trial of autologous MAGE-C2-specific TCR-engineered T cells in melanoma and head and neck squamous cell carcinoma (HNSCC), sponsored by Erasmus MC. Primary endpoints: Adverse events, Recommended Phase II dose and 4 more. Started Oct 2020; status: recruiting.

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Drugs

autologous MAGE-C2-specific TCR-engineered T cells
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Conditions

melanomahead and neck squamous cell carcinoma (HNSCC)

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