Trial intelligence / Profile preview

Tovorafenib versus standard chemotherapy in first-line pediatric low-grade glioma with RAF alteration

NL-OMON53920Phase 3Recruiting

Sponsor
Day One Biopharmaceuticals
Start
Feb 2023
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Countries
1
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Overview

Phase 3, randomised, open-label trial of tovorafenib in childhood low-grade glioma (pLGG), glioma and Glioneuronal Neoplasm, sponsored by Day One Biopharmaceuticals. Primary endpoint: Objective response rate. Started Feb 2023; status: recruiting.

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Drugs

tovorafenib
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Conditions

childhood low-grade glioma (pLGG)gliomaGlioneuronal Neoplasm

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