Trial intelligence / Profile preview

Validation of circulating predictive biomarkers for FOLFIRINOX response in pancreatic ductal adenocarcinoma

NL-OMON55991Active, not recruiting

Sponsor
Erasmus MC
Start
Jun 2021
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Open-label trial of fluorouracil, folinic acid, irinotecan, oxaliplatin, gemcitabine and 1 more in pancreatic adenocarcinoma (PDAC) and pancreatic cancer (PC) (2 cohorts), sponsored by Erasmus MC. Primary endpoints: Validation of circulating TP53 mutation and TP53 Pro72Arg germline variant as predictors of progressive disease during FOLFIRINOX and Validation of circulating microRNA biomarkers for prediction of progressive disease during FOLFIRINOX. Started Jun 2021; status: active, not recruiting.

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Drugs

fluorouracilfolinic acidirinotecanoxaliplatingemcitabine
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Conditions

pancreatic adenocarcinoma (PDAC)pancreatic cancer (PC)

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