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Phase 2 study of frexalimab, brivekimig, or rilzabrutinib versus placebo in primary FSGS or minimal change disease
NL-OMON58825Phase 2Recruiting
- Sponsor
- Sanofi
- Start
- Dec 2025
- Modality
- Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Countries
- 1
01
Overview
Phase 2, randomised, double-blind trial of frexalimab, brivekimig and rilzabrutinib in focal segmental glomerulosclerosis (FSGS) and nephrosis (4 arms), sponsored by Sanofi. Primary endpoint: Percent reduction in urine protein to creatinine ratio. Started Dec 2025; status: recruiting.
02
Drugs
frexalimabbrivekimigrilzabrutinib
03
Conditions
focal segmental glomerulosclerosis (FSGS)nephrosis
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