Trial intelligence / Profile preview

KEYNOTE-365 pembrolizumab combination therapies in metastatic castration-resistant prostate cancer

NL-OMON59100Phase 2Active, not recruiting

Sponsor
Merck & Co.
Start
Feb 2022
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules
Countries
1
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Overview

Phase 2, open-label trial of pembrolizumab, olaparib and carboplatin in metastatic castration-resistant prostate cancer (mCRPC) (10 cohorts), sponsored by Merck & Co. Primary endpoints: Percentage of participants with a decrease of at least 50% in prostate-specific antigen, Number of participants with adverse events and 2 more. Started Feb 2022; status: active, not recruiting.

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Drugs

pembrolizumabolaparibcarboplatin
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Conditions

metastatic castration-resistant prostate cancer (mCRPC)

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