Trial intelligence / Profile preview

LOTIS 5: loncastuximab tesirine + rituximab versus immunochemotherapy in relapsed or refractory diffuse large B-cell lymphoma

NL-OMON60048Phase 3Completed

Sponsor
ADC Therapeutics
Start
Nov 2022
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Countries
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Overview

Phase 3, randomised trial of loncastuximab tesirine and rituximab in diffuse large B-cell lymphoma (DLBCL) and large-cell lymphoma (2 arms), sponsored by ADC Therapeutics. Primary endpoint: Progression-free survival. Started Nov 2022; status: completed.

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Drugs

loncastuximab tesirinerituximab
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Conditions

diffuse large B-cell lymphoma (DLBCL)large-cell lymphoma

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