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HEM-iSMART Sub-protocol B: dasatinib + venetoclax in relapsed or refractory pediatric leukemia or lymphoma with MAPK/SRC pathway alterations
NL-OMON60636Phase 2Not yet recruiting
- Sponsor
- Princess Máxima Center for Pediatric Oncology
- Start
- Sep 2025
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 2, open-label, single-arm trial of dasatinib and venetoclax in acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL), sponsored by Princess Máxima Center for Pediatric Oncology. Primary endpoints: Maximum tolerated dose / recommended phase 2 dose and Best overall response rate. Planned start Sep 2025; status: not yet recruiting.
02
Drugs
dasatinibvenetoclax
03
Conditions
acute lymphoblastic leukemia (ALL)lymphoblastic lymphoma (LL)
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