Trial intelligence / Profile preview

Divarasib plus pembrolizumab versus pembrolizumab plus pemetrexed and platinum for untreated KRAS G12C-mutated advanced non-squamous NSCLC

NL-OMON60912Phase 3Suspended

Sponsor
Roche
Start
Dec 2025
Modality
Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Countries
1
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Overview

Phase 3, randomised trial of divarasib, pembrolizumab, pemetrexed, carboplatin and cisplatin in non-small cell lung cancer (NSCLC) (2 arms), sponsored by Roche. Primary endpoints: Progression-free survival and Overall survival. Started Dec 2025; status: suspended.

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Drugs

divarasibpembrolizumabpemetrexedcarboplatincisplatin
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Conditions

non-small cell lung cancer (NSCLC)

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