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20-19 Tan BB06oz CAR T
- Development stage
- Unknown
- Lead developer
- Roswell Park Comprehensive Cancer Center
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
20-19 Tan BB06oz CAR T is an autologous, bispecific chimeric antigen receptor (CAR) T-cell therapy developed by Roswell Park Cancer Institute. It is designed to simultaneously target two B-cell antigens, CD19 and CD20, to reduce the risk of antigen escape, a common cause of relapse in single-target CAR-T therapies. The CAR construct is unique in its incorporation of tandem (Tan) signaling domains, specifically utilizing both a 4-1BB costimulatory domain and a mutated CD28 costimulatory domain to enhance T-cell persistence and potency. It is currently being evaluated in Phase I clinical trials for patients with relapsed or refractory CD19+ aggressive hematologic malignancies, including various types of B-cell lymphoma.
- Other names
- CD19/CD20 bispecific CAR-T cells with 4-1BB and mutated CD28 costimulatory domains
02
Targets
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