Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ACBI3
- Development stage
- Preclinical
- Lead developer
- Boehringer Ingelheim
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Subcutaneous, Intraperitoneal
01
Overview
ACBI3 is a small-molecule pan-KRAS degrader developed through a collaboration between the University of Dundee and Boehringer Ingelheim. As a heterobifunctional proteolysis-targeting chimera (PROTAC), ACBI3 consists of a ligand that binds to multiple oncogenic KRAS mutants linked to a ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase. This recruitment facilitates the polyubiquitination of KRAS proteins, marking them for subsequent degradation by the 26S proteasome. ACBI3 has demonstrated the ability to degrade 13 of the 17 most common KRAS alleles (including G12D, G12V, and G13D) in preclinical models, providing a proof-of-concept for a 'pan-degrader' approach to treat a wide spectrum of KRAS-driven cancers, such as lung, colorectal, and pancreatic malignancies.
- Other names
- pan-KRAS degrader
02
Targets
VHL (Von Hippel–Lindau tumor suppressor protein)KRAS (Kirsten rat sarcoma viral oncogene homolog)
Beyond the preview
Go deeper on ACBI3.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ACBI3.