Drug intelligence / Profile preview

acetylsalicylic acid + dimethyl fumarate

Development stage
Preclinical
Lead developer
Vitalis Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Acetylsalicylic acid + dimethyl fumarate is a proprietary combination drug that pairs aspirin with dimethyl fumarate to reduce the incidence and severity of fumarate flush, a common side effect of dimethyl fumarate therapy in multiple sclerosis patients. Dimethyl fumarate is used to treat relapsing forms of multiple sclerosis, while the addition of aspirin helps mitigate the flushing side effect without affecting the pharmacokinetic profile of dimethyl fumarate or causing additional gastrointestinal events. In clinical studies, this combination has shown a 63% reduction in flush compared to fumarate alone.

Brand names
VTS-72VTS72VTS 72
Other names
aspirin + dimethyl fumarate
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Cellular cysteine-containing proteinsKEAP1 (Kelch-like ECH-associated protein 1)PGHS-1 (Prostaglandin G/H Synthase 1)

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