ag490

**AG490** is a synthetic small molecule that acts as a potent and selective inhibitor of Janus kinase 2 (JAK2) and is also known to inhibit epidermal growth factor receptor (EGFR) tyrosine kinase autophosphorylation. AG490 disrupts the JAK2/STAT pathway, inhibiting cell growth, inducing apoptosis, and blocking DNA synthesis in certain cancer cell lines such as acute lymphoblastic leukemia (ALL). It is widely used as a research tool to study JAK/STAT signaling mechanisms, inflammation, pain models, and cytokine signaling. AG490 is cell-permeable and shows selectivity over other tyrosine kinases, with little effect on normal hematopoiesis. Its effects on blocking IL-6 cytokine signaling and reducing inflammatory markers have been demonstrated in various models. The compound is not approved for human use and is restricted to in vitro or laboratory research applications[1][2][3][4][5][6][7][8][9][10].

Brand names

AG490AG-490AG 490

Other names

Tyrphostin AG490Tyrphostin B42α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamideN-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide