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allogeneic NK cells + rituximab + tafasitamab + interleukin-2
- Development stage
- Unknown
- Lead developer
- Case Comprehensive Cancer Center
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Monoclonal Antibodies → Antibody-Based Therapeutics, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
This investigational combination immunotherapy is being evaluated for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma. The regimen consists of donor-derived (allogeneic) natural killer (NK) cells administered in conjunction with two monoclonal antibodies: rituximab, which targets the CD20 antigen, and tafasitamab, which targets the CD19 antigen. The NK cells serve as immune effector cells intended to enhance antibody-dependent cellular cytotoxicity (ADCC) against lymphoma cells coated with these antibodies. Interleukin-2 (IL-2) is co-administered to support the activation, survival, and proliferation of the infused NK cells. The treatment is typically preceded by a lymphodepleting conditioning regimen of fludarabine and cyclophosphamide to facilitate the persistence of the allogeneic cells.
- Other names
- Allogeneic NK cells with Rituximab and TafasitamabRituximab and Tafasitamab in Combination With Allogeneic NK CellsAllogeneic NK cells-Paolo Caimi, MD-B-cell non-Hodgkin lymphoma
02
Targets
FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)IL-2R (Interleukin-2/interleukin-15 receptor complex)CD19 (B lymphocyte antigen CD19)CD20 (B-lymphocyte antigen CD20)
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