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ALY-101

Development stage: Unknown
Lead developer: Alys Pharmaceuticals
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intradermal, Transdermal

Overview

ALY-101 is an investigational drug developed by Alys Pharmaceuticals for the treatment of alopecia areata, a chronic autoimmune disease that causes hair loss. It is formulated as an intradermal injectable and utilizes a small interfering RNA (siRNA)-lipid conjugate to selectively target and silence Janus kinase 1 (JAK1), a key driver of inflammation in alopecia areata. The siRNA platform was developed in collaboration with Nobel Laureate Craig Mello and offers potential applications across multiple dermatological indications. ALY-101 is currently being evaluated in Phase IIa clinical trials for alopecia areata, with additional trans-epidermal formulations under development for atopic dermatitis and vitiligo.

Targets

JAK1 (Janus kinase 1)

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