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Ambrosia Biosciences is developing a small molecule amylin receptor agonist for the treatment of obesity and metabolic disorders. Currently in the discovery phase, the program is being designed for once-daily administration, either as a monotherapy or in combination with other metabolic therapies such as GLP-1 receptor agonists. The development process integrates cryo-EM-enabled structural biology, biophysical binding assays, and AI-powered molecular design. By targeting the amylin receptor as an agonist, the drug aims to mimic the physiological effects of amylin on satiety and glucose homeostasis, potentially offering an oral alternative to existing peptide-based injectable treatments.
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