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anti-Der p 1 IgG
- Development stage
- Preclinical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
anti-Der p 1 IgG is a monoclonal antibody designed to target the house dust mite (HDM) allergen Der p 1. Unlike traditional allergen-specific therapies that focus on neutralizing allergens or blocking IgE, this IgG antibody works through a neuroimmune axis involving the activation of Fc gamma receptors (FcγRs) on macrophages. This activation suppresses IgE-mediated itch circuits, including both histaminergic and leukotriene pathways. Research presented at AAAI 2026 demonstrated that a single dose of anti-Der p 1 IgG could significantly reduce scratching behavior in mouse models of atopic dermatitis and HDM-induced allergic itch, suggesting a potential therapeutic role for protective IgG antibodies in chronic pruritic disorders.
- Other names
- anti-DerP1 IgGanti-DerP-1 IgGanti-DerP 1 IgGanti-Der p 1 monoclonal antibody
02
Targets
Der p 1 (Dermatophagoides pteronyssinus allergen 1)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)
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