antrocinol

Antrocinol is a natural compound isolated from certain fungi and is being investigated as a potential agent for the treatment of hepatocellular carcinoma (HCC, also known as liver cancer). It is a small molecule of the decahydro-1H-naphtho[1,8a-c]furan-1-one class. Preclinical studies demonstrate that antrocinol suppresses tumor growth, induces apoptosis in cancer cell lines, inhibits cancer stem cell markers, and acts synergistically with existing therapies such as sorafenib. Mechanistically, antrocinol downregulates KRAS-GTP, p-MEK1/2, p-ERK1/2, and p-AKT, suggesting inhibition of the KRAS/MAPK and PI3K/AKT signaling pathways. It is not known to be an approved pharmaceutical; its primary indications under investigation are hepatocellular carcinoma and inhibition of hepatoma cancer stem cells[5][7][13].

Other names

(3aS,4R,6aS,10aR)-4-(hydroxymethyl)-7,7-dimethyldecahydro-1H-naphtho[1,8a-c]furan-1-one