Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
APG-1252 + ruxolitinib
- Development stage
- Unknown
- Lead developer
- Ascentage Pharma
- Modality
- Small Molecules
- Administration
- Oral (for Ruxolitinib), Intravenous (for APG-1252)
01
Overview
**APG-1252 + ruxolitinib** is an investigational combination therapy comprising APG-1252 (pelcitoclax), a dual inhibitor of anti-apoptotic BCL-2 family proteins (notably BCL-2 and BCL-xL), and ruxolitinib, an inhibitor of Janus kinase 1 and 2 (JAK1 and JAK2). APG-1252 induces apoptosis in cancer cells by blocking survival pathways, whereas ruxolitinib inhibits JAK-mediated cytokine signaling involved in myeloproliferative neoplasms. The combination is under study particularly for myelofibrosis and other hematologic malignancies where resistance to JAK inhibition occurs, with the proposed rationale that APG-1252 may overcome resistance mechanisms via enhanced apoptosis[6][7][9].
- Brand names
- pelcitoclax (for APG-1252)Jakafi (for ruxolitinib)
- Other names
- APG-1252 + ruxolitinibpelcitoclax + ruxolitinib
02
Targets
TYK2 (Tyrosine kinase 2)JAK2 (Janus kinase 2)TNK2 (Activated Cdc42-associated kinase 1)ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)BCL2L1 (B-cell lymphoma-extra large protein)LCK (Proto-oncogene tyrosine-protein kinase Lck)JAK1 (Janus kinase 1)SRC (Proto-oncogene tyrosine-protein kinase Src)JAK3 (Janus kinase 3)RET (Rearranged during transfection receptor tyrosine kinase)NTRK2 (Tropomyosin-related kinase receptor type B)
Beyond the preview
Go deeper on APG-1252 + ruxolitinib.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on APG-1252 + ruxolitinib.