Drug intelligence / Profile preview

avatrombopag + daratumumab + dexamethasone + eltrombopag + fostamatinib + mycophenolate mofetil + rituximab

Development stage
Unknown
Lead developer
Sobi
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination regimen consisting of seven distinct pharmaceutical agents, each with different mechanisms of action and indications. The drugs included are: - **Avatrombopag** and **Eltrombopag** (thrombopoietin receptor agonists) stimulate platelet production for the treatment of thrombocytopenia[1][5][6]. - **Daratumumab** (a monoclonal antibody targeting CD38) is primarily used in multiple myeloma. - **Dexamethasone** (a synthetic glucocorticoid corticosteroid) has anti-inflammatory and immunosuppressive effects. - **Fostamatinib** (a spleen tyrosine kinase inhibitor) is used for chronic immune thrombocytopenia. - **Mycophenolate mofetil** (an immunosuppressant that inhibits inosine monophosphate dehydrogenase) is commonly used to prevent organ rejection or treat autoimmune diseases. - **Rituximab** (a monoclonal antibody targeting CD20 on B cells) is indicated for various hematologic malignancies and autoimmune disorders. This combination does not correspond to any approved fixed-dose product or standard clinical regimen but represents a multi-agent protocol potentially designed for severe, refractory immune-mediated cytopenias or complex hematologic conditions. Each component acts via a distinct pathway affecting immune modulation, B-cell depletion, platelet stimulation, or suppression of autoantibody production.

02

Targets

CD20 (B-lymphocyte antigen CD20)LCK (Proto-oncogene tyrosine-protein kinase Lck)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)LYN (LYN proto-oncogene, Src family tyrosine kinase)GR (Glucocorticoid receptor)CD38 (Cluster of Differentiation 38)SYK (Spleen Tyrosine Kinase)FLT3 (Fms related receptor tyrosine kinase 3)

Beyond the preview

Go deeper on avatrombopag + daratumumab + dexamethasone + eltrombopag + fostamatinib + mycophenolate mofetil + rituximab.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on avatrombopag + daratumumab + dexamethasone + eltrombopag + fostamatinib + mycophenolate mofetil + rituximab.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call