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azathioprine + curcumin
- Development stage
- Preclinical
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of azathioprine, an immunosuppressant used to prevent renal transplant rejection and treat inflammatory conditions, and curcumin, a natural compound from turmeric with anti-inflammatory properties. The combination may have potential applications in treating inflammatory conditions, particularly ulcerative colitis. Curcumin may decrease the metabolism of azathioprine, potentially affecting its efficacy and side effect profile.
02
Targets
NF-κBRAC1 (Rac family small GTPase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IKK complex
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