azathioprine + cyclosporine + methylprednisolone

This is a combination of three immunosuppressive drugs—azathioprine, cyclosporine, and methylprednisolone—used primarily to prevent organ transplant rejection and to treat certain autoimmune diseases.

• Azathioprine is a purine analogue antimetabolite that acts as an immunosuppressant by inhibiting DNA and RNA synthesis in proliferating cells, particularly lymphocytes.
• Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation by inhibiting the transcription of interleukin-2 (IL-2) and other cytokines.
• Methylprednisolone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties; it modulates gene expression to reduce inflammation and immune responses.

This triple-drug regimen is commonly used in solid organ transplantation (such as kidney transplants) to prevent graft rejection by targeting multiple pathways of the immune response. It may also be used for severe autoimmune conditions when monotherapy or dual therapy are insufficient.