Drug intelligence / Profile preview

azathioprine + prednisone + ustekinumab + vancomycin

Development stage
Preclinical
Lead developer
GSK
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous, Subcutaneous
01

Overview

This is a combination of four medications used in the treatment of inflammatory bowel diseases, particularly severe or complicated cases of Crohn's disease or ulcerative colitis. The combination includes:\n\n- **Azathioprine**: An immunosuppressant that reduces inflammation by suppressing the immune system\n- **Prednisone**: A corticosteroid that reduces inflammation\n- **Ustekinumab**: A monoclonal antibody that targets specific inflammatory pathways\n- **Vancomycin**: A glycopeptide antibiotic used to treat bacterial infections, particularly Clostridioides difficile infections that can complicate inflammatory bowel disease

02

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)D-Ala-D-Ala (D-Ala-D-Ala terminus)IL12B (Interleukin-12/23 p40 subunit)

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