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Biocell Natural Killer Mixture + R-CHOP

Development stage
Preclinical
Lead developer
Nankai Biotech
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Cell Therapies, Small Molecules
Administration
Intravenous, Oral
01

Overview

**Biocell Natural Killer Mixture + R-CHOP** is a combination therapy that consists of a preparation referred to as "Biocell Natural Killer Mixture" (which is likely a supplement, preparation, or product designed to enhance or provide natural killer (NK) cell activity) and the established R-CHOP chemotherapy regimen. R-CHOP is widely used as first-line treatment for various B-cell non-Hodgkin lymphomas and is composed of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. The intended mechanism behind combining an NK cell-activator with R-CHOP is to potentially improve antitumor efficacy by synergistically enhancing immune-mediated cytotoxicity alongside cytotoxic chemotherapy and monoclonal antibody therapy[2][5][4].

02

Targets

CD20 (B-lymphocyte antigen CD20)GR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)

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