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BJ045 is an investigational recombinant protein therapeutic being developed by Shanghai Bao Pharmaceuticals for the treatment of IgG-mediated autoimmune diseases. Currently in the preclinical stage of development, BJ045 is designed to rapidly deplete circulating Immunoglobulin G (IgG) antibodies, which are the primary drivers of pathology in various autoimmune conditions. It is positioned within the developer's pipeline alongside Ricefidase (KJ103), a recombinant IgG-degrading enzyme (IdeS), suggesting that BJ045 may utilize a similar enzymatic mechanism to cleave or degrade pathogenic autoantibodies to alleviate disease symptoms.
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