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Bv-NVD-R
- Development stage
- Unknown
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Vaccines & Immunotherapeutics, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Bv-NVD-R is a targeted immunotherapy combination regimen consisting of brentuximab vedotin (Bv), nivolumab (N), vinblastine (V), dacarbazine (D), and rituximab (R). This combination therapy is being studied in clinical trials for treating classical Hodgkin lymphoma (cHL) in pediatric, adolescent, and young adult patients. The regimen is part of a risk-adapted approach to treatment, where patients are classified as either Rapid Early Responders (RER) or Slow Early Responders (SER) based on FDG-PET scan results after initial treatment cycles. This classification determines the subsequent treatment protocol.
- Other names
- Bv-NVD-R regimen
02
Targets
CD30 (CD30 antigen)TUBB (Tubulin (alpha and beta subunits))CD20 (B-lymphocyte antigen CD20)PDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)
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