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c-JUN siRNA
- Development stage
- Preclinical
- Lead developer
- University of South Florida
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
c-JUN siRNA is a small interfering RNA (siRNA) designed to silence the expression of the c-Jun protein, a critical component of the Activator Protein-1 (AP-1) transcription factor complex. By targeting the mRNA of the JUN gene, this siRNA prevents the translation of c-Jun, thereby inhibiting its downstream signaling pathways involved in cell proliferation, migration, and survival. In oncological research, c-JUN siRNA has been investigated for its ability to suppress the growth and metastasis of various cancers, including pancreatic, prostate, and melanoma, often by downregulating oncogenic targets like PKC-ι or matrix metalloproteinases. It is also used in respiratory research to study the regulation of inflammatory receptors in airway smooth muscle cells.
- Other names
- c-Jun siRNAc-JUN (AP1) siRNAsiRNA targeting human endogenous c-Jun
02
Targets
JUN (Transcription factor Jun)
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