CA-STAT5

CA-STAT5 refers to a constitutively active mutant form of the Signal Transducer and Activator of Transcription 5 (STAT5) protein. It is primarily utilized in research and preclinical development as a genetic modification for adoptive cell therapies (ACT), such as TCR-engineered T cells. By providing continuous STAT5 signaling independent of external cytokine stimulation (e.g., IL-2 or IL-15), CA-STAT5 enhances T-cell expansion, persistence, and polyfunctionality. Research indicates that CA-STAT5-engineered T cells demonstrate superior antitumor activity in models like B16F10 melanoma by reducing PD-1 expression and attenuating the PD-1/PD-L1 inhibitory pathway, thereby decreasing cellular exhaustion. Additionally, it is used as a laboratory tool to investigate the role of STAT5 signaling in dendritic cell differentiation and the pathogenesis of myeloid neoplasms.

Other names

constitutively active STAT5constitutively active Signal Transducer and Activator of Transcription 5