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CAR-T cells targeting B7-H3 and PTGFRN
- Development stage
- Preclinical
- Lead developer
- Osaka University
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intratumoral, Intravenous
01
Overview
CAR-T cells targeting B7-H3 and PTGFRN are an experimental chimeric antigen receptor T-cell therapy being developed for the treatment of glioblastoma. B7-H3 (CD276) and PTGFRN (Prostaglandin F2 receptor inhibitor) were identified as tumor-specific surface antigens highly expressed in glioblastoma surgical specimens but not in normal brain tissue. In preclinical studies conducted at Osaka University, these CAR-T cells demonstrated significant anti-tumor activity, including increased production of IL-2 and IFN-γ upon co-culture with GBM cells and reduced tumor growth in orthotopic xenograft models. The therapy aims to overcome the challenges of glioblastoma treatment, such as the blood-brain barrier and the immunosuppressive tumor microenvironment.
- Other names
- B7-H3/PTGFRN CAR-T cells
02
Targets
PTGFRNB7-H3
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