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Drug intelligence / Profile preview
CART-19 and 20 cells
- Development stage
- Preclinical
- Lead developer
- Henan Cancer Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**CART-19 and 20 cells** is an investigational dual-target chimeric antigen receptor T-cell therapy developed by Henan Cancer Hospital for relapsed or refractory CD19-positive/CD20-positive B-cell non-Hodgkin lymphoma. The product is designed to direct engineered T cells against both CD19 and CD20 on malignant B cells, promoting CAR-mediated T-cell activation and cytotoxic elimination of antigen-expressing lymphoma cells. It is being evaluated following cyclophosphamide and fludarabine lymphodepleting preconditioning in the registered single-group clinical study NCT06160362. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06160362))
- Other names
- CD19/CD20 chimeric antigen receptor T cellsdouble-target CART-19 and 20 cells
02
Targets
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