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CD3-CD20 bispecific antibody
- Development stage
- Preclinical
- Lead developer
- Benhealth Biopharmaceutical
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Oral, Topical, Subcutaneous, Intravenous, Intramuscular, Inhalation, Intranasal, Rectal, Vaginal, Intradermal, Intravitreal, Intratumoral, Intralesional, Intraperitoneal, Intra-arterial, Percutaneous, Parenteral, Implant
01
Overview
The CD3-CD20 bispecific antibody is a preclinical-stage T-cell engaging therapeutic being developed by Benhealth Biopharmaceutical. Engineered using the company's proprietary ExMab platform, the antibody is designed to bridge T-cells and B-cells by simultaneously targeting the CD3 epsilon subunit of the T-cell receptor complex and the CD20 antigen expressed on the surface of B-lymphocytes. This mechanism of action triggers the formation of an immunological synapse, leading to the activation and proliferation of cytotoxic T-cells and the subsequent directed lysis of CD20-positive cells. The program is intended for the treatment of various B-cell malignancies, including non-Hodgkin lymphoma and chronic lymphocytic leukemia, where CD20 is a well-validated therapeutic target.
- Other names
- CD3/CD20 bispecific antibodyanti-CD3 x anti-CD20 bispecific antibodyanti-CD-3 x anti-CD20 bispecific antibodyanti-CD 3 x anti-CD20 bispecific antibody
02
Targets
CD20 (B-lymphocyte antigen CD20)CD3 (T-cell surface glycoprotein CD3)
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