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cinnamon bark oil
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Cinnamon bark oil is an essential oil extracted from the bark of cinnamon trees, primarily Cinnamomum verum (Ceylon cinnamon) or Cinnamomum cassia. It is widely recognized for its potent antimicrobial, antifungal, and antibiofilm properties, which are largely attributed to its high concentration of active constituents such as cinnamaldehyde and eugenol. In preclinical studies, cinnamon bark oil has demonstrated strong biocidal activity against various bacterial and yeast pathogens, including Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa, making it a subject of interest for combating surgical site infections and multidrug-resistant biofilms.
- Other names
- Ceylon cinnamon bark oilCinnamomum cassia bark oilCinnamomum verum bark oilcinnamon bark essential oil
02
Targets
ACE2 (Angiotensin-converting enzyme 2)AHR (Aryl hydrocarbon receptor)HDAC1 (Histone Deacetylase 1)JAK2 (Janus kinase 2)MAOB (Monoamine oxidase B)MMP2 (Matrix metalloproteinase-2)NeuraminidaseOR (Olfactory receptors)PARP1 (Poly (adp-ribose) polymerase 1)PPARA (Peroxisome proliferator-activated receptor alpha)PXR (Pregnane X receptor)TLR4 (Toll-like receptor 4)TMPRSS2 (Transmembrane protease serine 2)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TYR (Tyrosinase)
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