ciprofloxacin + cloxacillin

Ciprofloxacin + cloxacillin is a fixed-dose combination antibiotic therapy used to treat a variety of bacterial infections. Ciprofloxacin, a second-generation fluoroquinolone, provides broad-spectrum activity, particularly against Gram-negative bacteria, by inhibiting DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, repair, and recombination. Cloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class that is resistant to staphylococcal penicillinase. It works by binding to penicillin-binding proteins (PBPs), thereby inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. This combination is often employed empirically for mixed infections or when resistant Gram-positive organisms like *Staphylococcus aureus* are suspected alongside Gram-negative pathogens.

Brand names

CiproloxCiflox-CCipro-CloxCipro-CCifloxin-C

Other names

ciprofloxacin and cloxacillin