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circular human interleukin-10 RNA
- Development stage
- Preclinical
- Lead developer
- University Health Network
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Inhalation
01
Overview
Circular human interleukin-10 RNA (circ hIL-10 RNA) is a closed-loop RNA therapeutic designed to express human interleukin-10 (hIL-10), a key anti-inflammatory and immunomodulatory cytokine. Formulated within lipid nanoparticles (LNPs) containing the ionizable lipid ST-1 and DOTAP, this circular RNA is resistant to exonuclease degradation, enabling more prolonged and sustained protein expression compared to linear mRNA. It is being investigated for gene therapy in donor lungs during ex vivo lung perfusion (EVLP) to mitigate ischemia-reperfusion injury and harmful immune responses during the acute post-lung transplant (LTx) phase.
- Other names
- circ hIL-10 RNAcircular human IL-10 RNAcircular human interleukin-10 mRNA
02
Targets
IL10 (Interleukin-10)IL10RA (Interleukin-10 Receptor)JAK1 (Janus kinase 1)STAT3 (Signal Transducer and Activator of Transcription 3)TYK2 (Tyrosine kinase 2)
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