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Drug intelligence / Profile preview
citronellol
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Inhalation, Topical, Oral
01
Overview
Citronellol is a naturally occurring acyclic monoterpenoid alcohol found in various essential oils, including geranium, rose, and citronella. It is widely utilized in the fragrance and cosmetic industries for its floral, rose-like scent and is also used as a flavoring agent in the food industry. Beyond its commercial applications, citronellol is being investigated for several therapeutic roles, including its potential as an anti-inflammatory, analgesic, and antineoplastic agent. Research suggests it can potentiate the efficacy of tyrosine kinase inhibitors like sunitinib in renal cell carcinoma by inhibiting the JAK2/STAT3 and EGFR signaling pathways. Additionally, it has been explored as a component of lipid nanoparticles for mRNA delivery and as a natural antifungal and acaricidal agent. In clinical settings, it is often administered via aromatherapy to manage fatigue and improve sleep quality in patients with chronic conditions such as end-stage renal disease.
- Other names
- beta-citronellol3,7-dimethyl-6-octen-1-oldihydrogeraniol(±)-citronellol
02
Targets
CASP3 (Caspase-3)CASP8 (Caspase-8)JAK2 (Janus kinase 2)NF-κBTNFA (Tumor necrosis factor alpha (soluble))EGFR (Epidermal growth factor receptor)HMOX1 (Heme oxygenase 1)MMP2 (Matrix metalloproteinase-2)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)STAT3 (Signal Transducer and Activator of Transcription 3)JUN (Transcription factor Jun)
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