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colaspase + mercaptopurine + prednisolone + vincristine
- Development stage
- Unknown
- Lead developer
- Bayer HealthCare Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination chemotherapy regimen used primarily for the treatment of acute lymphoblastic leukemia (ALL). This regimen combines four agents with different mechanisms of action: colaspase (L-asparaginase/PEG-asparaginase) which depletes asparagine essential for leukemic cell survival, mercaptopurine which interferes with nucleic acid biosynthesis, prednisolone which has anti-inflammatory and immunosuppressive properties, and vincristine which disrupts microtubule formation preventing cell division. This combination is used in various phases of ALL treatment including induction, consolidation, and maintenance therapy.
- Other names
- L-asparaginase + mercaptopurine + prednisolone + vincristinePEG-asparaginase + mercaptopurine + prednisolone + vincristine
02
Targets
GR (Glucocorticoid receptor)TUBB (Tubulin (alpha and beta subunits))
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