colistin + piperacillin + tazobactam

Colistin + piperacillin + tazobactam is a combination of three antibiotics used together, typically in hospital settings, to treat severe or multidrug-resistant bacterial infections. Colistin is a polymyxin antibiotic that disrupts the bacterial cell membrane of Gram-negative bacteria. Piperacillin is an extended-spectrum penicillin (ureidopenicillin) that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Tazobactam is a β-lactamase inhibitor that protects piperacillin from enzymatic degradation by β-lactamase-producing bacteria, thereby extending its spectrum of activity. This combination may be considered for infections caused by multidrug-resistant organisms, especially when monotherapy has failed or resistance patterns warrant broad-spectrum coverage[1][4][5][7].