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01
Overview
Compound A (Pfizer): sourced facts only. name: "We utilized an in-house developed KRAS G12C inhibitor (Compound A) as a tool to demonstrate the value of this framework in studying in vivo pharmacokinetic/pharmacodynamic (PK/PD) relationship and anti-tumor efficacy." [PMID:37186518]; target: "We utilized an in-house developed KRAS G12C inhibitor (Compound A) as a tool to demonstrate the value of this framework in studying in vivo pharmacokinetic/pharmacodynamic (PK/PD) relationship and anti-tumor efficacy." [PMID:37186518]; developer: "Oncology Research and Development, Pfizer Inc., Worldwide Research, Development and Medical, San Diego, California." [PMID:37186518]; stage: "We also find that Compound A has comparable efficacy to sotorasib in the Kras G12C-driven lung tumors arising in the GEMM, but like observations in the clinic, some tumors inevitably progress on treatment." [PMID:37186518]
02
Targets
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