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coptis prescription granules
- Development stage
- Unknown
- Lead developer
- Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Coptis prescription granules are a standardized herbal extract derived from the rhizome of *Coptis chinensis* (Huang Lian), a prominent herb in Traditional Chinese Medicine (TCM) known for its "cold" property. It is primarily used to clear heat, dry dampness, and purge fire according to TCM principles. The primary active constituent is berberine, an isoquinoline alkaloid with significant antimicrobial, anti-inflammatory, and metabolic regulatory effects. In clinical research conducted by Dongzhimen Hospital and Beijing University of Chinese Medicine, these granules are studied for their impact on gut microbiota composition, bowel habits, sleep quality, and blood proteomics in healthy individuals to elucidate the biological basis of the TCM "four properties" (cold, hot, warm, and cool) theory.
- Other names
- Huang Lian prescription granulesHuanglian prescription granulesCoptis chinensis granulesHuanglian granules
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)
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