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coumermycin a1
- Development stage
- Preclinical
- Lead developer
- Streptomyces rishiriensis (natural producer)
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Not Established For Clinical Use; Experimental Only (typically Used In Vitro Or Laboratory Research)[3][6]
01
Overview
Coumermycin A1 is an aminocoumarin antibiotic produced by Streptomyces rishiriensis. It acts primarily by binding to the ATPase site of the DNA gyrase GyrB subunit in bacteria. This inhibits ATP-dependent DNA supercoiling and thereby blocks bacterial DNA replication and cell division[2][5][8]. It has potent antibacterial activity against both Gram-positive and Gram-negative bacteria and has also demonstrated anticancer properties in preclinical studies[4][9]. In addition to its primary action on bacterial DNA gyrase (GyrB), it can act as a JAK2 signal activator in mammalian cells[3][6]. Its high affinity for bacterial gyrase makes it more effective than related antibiotics such as novobiocin[7].
- Other names
- CoumamycinNotomycin A1CumamycinumSugordomycin D-laCoumamycine [INN-French]Cumamicina [INN-Spanish]NSC-107412NSC107412NSC 107412
02
Targets
GyrB (DNA gyrase subunit B)JAK2 (Janus kinase 2)
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