Drug intelligence / Profile preview

curcumin + interferon beta-1a

Development stage
Unknown
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral, Intramuscular, Subcutaneous
01

Overview

Curcumin + interferon beta-1a is a combination therapy consisting of curcumin, a naturally occurring polyphenolic compound with anti-inflammatory and antioxidant properties, and interferon beta-1a, a recombinant protein used as an immunomodulatory agent in the treatment of multiple sclerosis (MS). Curcumin acts by modulating inflammatory pathways and oxidative stress, while interferon beta-1a reduces disease activity in MS by modulating immune responses. This combination has been investigated as an add-on therapy for relapsing multiple sclerosis to assess potential synergistic effects on inflammation and neurodegeneration. Clinical studies suggest that curcumin may enhance the radiological efficacy of interferon beta-1a on certain MRI markers of inflammation but does not provide additional neuroprotective or clinical benefit over interferon beta-1a alone[1][4].

Other names
curcumin and interferon beta-1aIFN-curcumin
02

Targets

IFNAR (Immune system modulation via type I interferon receptor)JAK (Janus kinase family)IFNGR1 (Interferon gamma receptor 1)STAT1 (Signal transducer and activator of transcription protein 1)

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