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cytarabine + leucovorin + methotrexate + procarbazine + rituximab + vincristine
- Development stage
- Preclinical
- Lead developer
- Memorial Sloan Kettering Cancer Center
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral, Intrathecal
01
Overview
This is a combination chemotherapy regimen containing cytarabine (a nucleoside analog), leucovorin (a reduced form of folate), methotrexate (an antimetabolite), procarbazine (an alkylating agent), rituximab (a monoclonal antibody targeting CD20), and vincristine (a vinca alkaloid). This combination is likely used in the treatment of certain types of lymphoma, particularly B-cell lymphomas. The regimen combines different mechanisms of action to target cancer cells through multiple pathways.
02
Targets
DNA polymerase familyCD20 (B-lymphocyte antigen CD20)TUBB (Tubulin (alpha and beta subunits))DHFR (Dihydrofolate reductase)DNA
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