DC-11

DC-11 is a synthetic D-peptide inhibitor designed to target the interaction between the Ras protein and its downstream effectors, such as Raf. Ras proteins are small GTPases that function as molecular switches in signaling pathways regulating cell growth, differentiation, and survival. Mutations in Ras are among the most common drivers in human cancers, leading to constitutive activation of the MAPK/ERK pathway. DC-11 was identified through mirror-image phage display, a technique used to discover D-peptides that bind to natural L-protein targets. By binding to the effector-binding loop of Ras, DC-11 competitively inhibits the recruitment of Raf, thereby blocking downstream oncogenic signaling. As a D-peptide, DC-11 offers potential advantages over traditional L-peptides, including enhanced proteolytic stability and reduced immunogenicity, making it an attractive candidate for therapeutic development in Ras-driven malignancies.

Other names

D-peptide Ras inhibitor